R.Du Hyun RoOrthopedics & Research
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knee shape and change · 2025

Does severe arthritis change the shape of the knee?

This study compares alignment distributions across 17,365 knees with different OA grades.

Journal of Bone and Joint Surgery American Volume · Sung Eun Kim, Samuel MacDessi, Daeseok Song, Joong Il Kim, Byung Sun Choi, Hyuk-Soo Han, Du Hyun Ro

Research question and design

CPAK, aHKA and JLO distributions were compared by KL grade in 17,365 knees.Enlarge Figure

CPAK, aHKA and JLO distributions were compared by KL grade in 17,365 knees.

Journal of Bone and Joint Surgery American Volume (2025). DOI: 10.2106/JBJS.24.00316 · Original explanatory chart based on reported data

Evidence & Original SourceImage use terms
01

I compared the arthritis rating with the leg shape together.

OA includes varied knee shapes. We automatically measured full-length X-rays of 17,365 knees to examine KL grade together with CPAK alignment. The study asks how shapes differ between unaffected and severe groups and whether age alone explains those differences.

02

The most common type of painting varies.

CPAK type II was more common at lower KL grades, while type I was more common at higher grades. Related angles changed in different directions. Reading the femoral surface angle, tibial surface angle, and the angle between the joint lines separately reveals information that the word “bowlegs” alone misses.

03

It was hard to explain what Naiman's problem was.

The association between arthritis severity and shape remained important in age-stratified analyses. Age alone does not explain a shared change in shape. Constitutional susceptibility and shape changes caused by OA remain possible explanations; longitudinal studies are needed to establish their sequence.

04

It's not a picture of a person's transformation.

This cross-sectional study compares different knees at one point in time. A smaller proportion of type II and larger proportion of type I does not mean that an individual necessarily changes from II to I. Group differences must not be read as a personal progression pathway.

05

The surgery plan looks at the current photo with its original form.

In arthroplasty research, we need to ask whether current deformity can be treated as the original shape. This paper sharpens that question. Separate comparative studies must establish which alignment philosophy gives better results; a classification name alone should not determine an individual’s operation.

Look at the study numbers again.

17,365Knees analyzed
KL gradeDiscrimination of OA severity
CPAKAlignment-type classification
RESEARCH FINDINGknee

Composition of the study sample

Knees analyzed
17,365
09,98519,970
Counts of data included in the study. These do not show treatment effects or an individual’s risk.

Common Questions

Can we apply these results directly to individual therapies?

In arthroplasty research, we need to ask whether current deformity can be treated as the original shape. This paper sharpens that question. Separate comparative studies must establish which alignment philosophy gives better results; a classification name alone should not determine an individual’s operation.

Methods and Numbers in Detail

Coronal Plane Alignment of the Knee (CPAK) Type Shifts Toward Constitutional Varus with Increasing Kellgren and Lawrence Grade: A Radiographic Analysis of 17,365 Knees

Participants and Methods

The analysis included 17,365 knees and excluded severe bone loss >5 mm, Ahlbäck grades 4–5, previous bone surgery and other specified conditions.

This retrospective cross-sectional study used AI imaging measurements to compare alignment measures by KL grade, CPAK type and age.

Results Reported in the Paper

  1. As KL increased, the most frequent CPAK type shifted from II to I (P < 0.05). LDFA and JLCA increased; HKAA, MPTA and aHKA decreased beyond KL 2.
  2. Associations of age with LDFA and MPTA were limited.

Scope of Interpretation

The study did not establish longitudinal changes in CPAK in individual patients. It cannot distinguish susceptibility to OA due to pre-existing varus from anatomical changes caused by OA.

Keywords

Abstract · Original text

Sung Eun Kim, Samuel MacDessi, Daeseok Song, Joong Il Kim, Byung Sun Choi, Hyuk-Soo Han, Du Hyun Ro. Coronal Plane Alignment of the Knee (CPAK) Type Shifts Toward Constitutional Varus with Increasing Kellgren and Lawrence Grade: A Radiographic Analysis of 17,365 Knees. The Journal of bone and joint surgery. American volume. 2025;107(3):297-303. doi:10.2106/JBJS.24.00316.

BACKGROUND

Studies investigating constitutional alignment across various grades of osteoarthritis (OA) are limited. This study explored the distribution of Coronal Plane Alignment of the Knee (CPAK) types and associated radiographic parameters with increasing OA severity.

METHODS

In this retrospective cross-sectional study, 17,365 knees were analyzed using deep learning software for radiographic measurements. Knees were categorized on the basis of the Kellgren and Lawrence (KL) grade and CPAK type. Radiographic measurements were the hip-knee-ankle angle (HKAA), lateral distal femoral angle (LDFA), medial proximal tibial angle (MPTA), arithmetic HKAA (aHKA), joint line obliquity (JLO), and joint line convergence angle (JLCA). Age-stratified analysis was performed to differentiate the impact of age on OA severity.

RESULTS

A shift in the most common CPAK type from II to I was found with increasing KL grade (p < 0.05). Furthermore, there was a corresponding increase in LDFA and JLCA with increasing KL grade, while HKAA, MPTA, and aHKA decreased after KL grade 2. Age exhibited limited association with LDFA and MPTA, suggesting that OA severity is the dominant factor related to the CPAK distribution.

CONCLUSIONS

The study found a shift in CPAK type with worsening OA. It is possible that constitutional varus types are more susceptible to OA, or that their increased OA prevalence is related to anatomical changes. This analysis offers new insights into alterations in CPAK type that occur with OA and underscores the importance of understanding pre-arthritic anatomy when performing joint reconstruction.

LEVEL OF EVIDENCE

Prognostic Level III . See Instructions for Authors for a complete description of levels of evidence.

Copyright © 2024 The Author(s). Published by The Journal of Bone and Joint Surgery, Incorporated.