R.Du Hyun RoOrthopedics & Research
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knee shape and change · 2026

Do both knees change in similar ways?

The knee’s own baseline condition was more strongly associated with alignment change than the opposite knee’s condition.

Cartilage · Kang KS et al. · Ro DH

Agreement of alignment types between knees

Bilateral FKP and CPAK agreement at baseline and follow-upEnlarge Figure

These are proportions of knees classified as the same type bilaterally: FKP 41.6% to 35.5%, CPAK 53.5% to 55.4%. Do not add the classifications or interpret them as symmetry of actual angles.

Bilateral knee alignment study · 3,045 patients · Original explanatory chart based on reported data

Evidence & Original SourceImage use terms
01

It's not like both knees are exactly the same shape.

If one knee hurts, you may wonder whether the other will change similarly. A less painful or less affected opposite knee can seem like a useful template. First, however, we need to ask whether the two knees of the same person always share an alignment type.

The study examined agreement in left–right knee shape and how one side’s imaging measures related to later alignment on the other. Its key approach was comparing analyses of each knee separately with analyses of both knees together.

02

3,045 Korean participants followed for an average of 4 years

Full-length X-rays of both legs assessed alignment at baseline and follow-up. FKP classifies femoral and tibial morphology; CPAK combines leg alignment and joint-line obliquity. We calculated the proportion of left and right knees sharing a category.

Groups were defined by baseline varus, neutral and valgus combinations. Measures associated with follow-up HKAA were analyzed, including both ipsilateral and contralateral measures to compare association strength.

03

The initial rate of the same CPAK type was 53.5%.

Baseline bilateral agreement was 41.6% for FKP and 53.5% for CPAK; after a mean 4.0 years, 35.5% and 55.4%. Depending on classification, only around half of a person’s knees shared a type. “Same type” means the same category, not identical angles.

Some opposite-knee measures were also associated with follow-up alignment. Their standardized regression coefficients, however, were smaller than those of the knee being assessed. This is different from concluding that opposite-knee information is irrelevant.

The rise in CPAK agreement from 53.5% to 55.4% does not prove that the knees became more symmetric. The original paper notes that a limited number of categories can group different angle changes within the same type.

04

The other side is, you have to look at knee separately.

And this shows that it's hard to replace the shape of the other side as a straight answer. Because the alignment type of the coordinates can be different, and subsequent changes are more strongly related to how knee was at first.

It's not necessarily better that they are different. The differences in the way we classify them in our studies and the problems that need to be treated are not the same questions. We can use this research to talk about how uncomfortable each of these is in the clinic, and what changes we see in each video.

05

It's not a study that tested the effects of one surgery on another.

“Contralateral influence” in the title should not be read as a treatment effect. This study analyzed statistical associations between imaging measures in both knees and later alignment. It did not compare contralateral outcomes in patients with versus without surgery.

These numbers alone cannot set target arthroplasty angles or show that surgery on one knee reduces OA progression in the other. The study asks how similar the information from the two knees is and how it relates to alignment change.

The participants were Korean hospital patients, with many varus knees. Applicability to valgus knees or people without OA needs further study. Imaging position and leg rotation can also affect measured angles.

Look at the study numbers again.

3,045The target patient.
4.0 yearsAverage tracking time
53.5%Initial CPAK matches both sides
RESEARCH FINDINGProportion (%)

The matching rate of the two-dimensional array type

Early.Tracking you.
FKP
41.6%
35.5%
CPAK
53.5%
55.4%
050100
This is the proportion of patients whose left and right knees had the same type. It does not represent the amount of alignment change in an individual.

Common Questions

Is it wrong if the right-hand side of knee is different?

In the same study, there were other types of left-handedness. It's not just the difference in categorization that determines the extent of a disease or the need for treatment.

Don't you need to see the knee photo on the other side?

That's not what it means. Some indicators on the other side are also relevant, but it's important to check together for information about knee.

Terms in This Article
CPAK
A classification combining leg alignment and joint-line obliquity to describe knee shape.
Follow-up observation
It's a way of looking at the same object again after a certain amount of time.
Methods and Numbers in Detail

Contralateral versus ipsilateral alignment parameters in knee osteoarthritis

Participants and Methods

South Koreans 3,045 · Average tracking 4.0 years

Agreement in FKP and CPAK types was calculated using bilateral full-length lower-limb radiographs. Regression analyses for each baseline alignment combination compared the relative associations of ipsilateral and contralateral measures.

Results Reported in the Paper

  1. At baseline, bilateral agreement was 41.6% for FKP and 53.5% for CPAK.
  2. At a mean follow-up of 4.0 years, CPAK agreement was 55.4%.
  3. Some contralateral measures were also associated with follow-up HKAA, but their standardized regression coefficients were smaller than those of ipsilateral measures.

Scope of Interpretation

These are observational findings on alignment progression, not a direct test of contralateral surgical effects or target alignment in arthroplasty.

Keywords

Abstract · Original text

Kee Soo Kang, Byung Sun Choi, Hyuk-Soo Han, Chong Bum Chang, Kwangho Chung, Du Hyun Ro. Contralateral Knee Alignment Parameters Have Limited Influence on Coronal Alignment Progression Compared With Ipsilateral Parameters in Patients With Knee Osteoarthritis. Cartilage. 2026:19476035261450111. doi:10.1177/19476035261450111.

ObjectiveTo compare alignment parameters in bilateral lower extremities and evaluate the effect of contralateral limb on hip-knee-ankle angle (HKAA) longitudinally.MethodsNative bilateral lower extremities of 3,045 Korean patients with long-leg radiographs were followed for progression of knee osteoarthritis. Concordance rates of Functional Knee Phenotypes (FKPs) and Coronal Plane Alignment of the Knee (CPAK), the proportion of patients with identical bilateral subtypes, were assessed. Varus, neutral, and valgus alignments were defined as baseline HKAA ≤177°, 177°< HKAA <183°, and HKAA ≥183°, respectively. Multivariable linear regressions for follow-up HKAA were conducted.ResultsConcordance rates for FKPs and CPAK were 41.6% (95% confidence interval: 39.9-43.4%) and 53.5% (51.7-55.2%), respectively, at baseline and 35.5% (33.8-37.2%) and 55.4% (53.7-57.2%) at a mean 4.0-year follow-up. Contralateral parameters, Kellgren-Lawrence grade (P = 0.005) in bilateral varus group, medial proximal tibial angle (MPTA) (P = 0.046) in ipsilateral varus-contralateral neutral group, MPTA, and mechanical lateral distal femoral angle in bilateral neutral (P < 0.001; P = 0.012, respectively) and valgus (P = 0.003; P = 0.004) groups, were associated with follow-up HKAA. However, their standardized β values were smaller than ipsilateral values.ConclusionConcordance rates of FKPs and CPAK between bilateral limbs were 41.6% and 53.5% at baseline, respectively. Contralateral parameters have limited influence on coronal alignment progression compared with ipsilateral parameters.

© The Author(s) 2026