R.Du Hyun RoOrthopedics & Research
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knee shape and change · 2025

Does knee alignment differ between people and countries?

When we compared hospital visitors from South Korea and the UAE, there was a slightly different sort of common knee.

Knee Surgery & Related Research · Park J et al. · Ro DH, Kim SE

Original Figure 2 · We examined both country means and the spread of the distributions

The AHKA and joint line slope of the JLO distribution in UAE and South Korea patients is shown above CPAK zone Figure 2.Enlarge Figure

Left is the UAE, right is the knee alignment distribution in Korea. The transverse axis is aHKA, which combines the alignment of bone, and the triangle axis JLO is the slope of joint line, where as the color gets deeper there's a lot more knee in that position. The dot zone in the dotted line represents CPAK type. The two diagrams show that instead of setting a country's knee as a single standard, we need to look at the diversity within and between groups together. It's the data of patients who were hospitalized with symptoms, so it doesn't make sense as a normal population distribution across the country.

Jisoon Park, Oussama Chaar, Jayakrishnan Narayanakurup, Alamedin Sobhe Abdelsamea Abdelhamead, Du Hyun Ro, Sung Eun Kim. Do knee alignment patterns differ between Middle Eastern and East Asian populations? A propensity-matched analysis using artificial intelligence. Knee Surgery & Related Research (2025). https://doi.org/10.1186/s43019-025-00261-w · Figure 2.

Evidence & Original SourceImage use terms
Original Figure Legend

Hexbin plots of CPAK classification of the UAE and South Korea

01

knee doesn't have just one average.

When I describe the knee alignment, I use familiar words like O- and X-step. In the actual video, you can see the alignment of the entire bridge divided by the slope of knee and joint line. Even a bridge that looks similar on the outside can be a combination of both.

This study compared hospital visitors in Korea and the UAE. It asked whether common alignment types were the same, and whether differences remained after accounting for age and sex—a starting point for studying individual knee variation.

02

I compared the X-rays to age and sex.

Before analysis, the data included 7,138 Korean and 1,098 UAE participants, comprising 16,472 knees in total. These were historical images from people attending hospitals with knee symptoms. AI software measured alignment angles and OA grades and classified CPAK types.

A simple comparison of group proportions may mix in differences in age and sex composition. The study therefore used 1:2 propensity-score matching for age and sex. Matching reduces differences in specified factors; it does not make every condition identical.

03

There were different patterns seen in men and women.

After matching, the most common male type was CPAK 1 in the UAE (42.4%) and CPAK 2 in Korea (30.6%). Women most often had type 2 in both populations: UAE 30.6%, Korea 35.3%. Breaking down sex and type explains the result more accurately than simply saying the countries differ.

The original plots show where individual knees fall within the classification. Many angles occur even within one named type. The most common type does not represent every knee in that population.

04

It's the basic data for studying individual surgery plans.

The results of the differing distributions in different groups show that it's difficult to describe all knee with just one average shape. In order to study the knee form and develop a surgery plan, we need to consider group characteristics together with individual video information.

But you can't just sort out a person from any country. We need to distinguish between group differences and individual conditions. Also, this study is not a clinical trial comparing which surgery angle is better for specific types of CPAK.

Even when the most common type differs by country, many types coexist within each country. Read the dense regions and the wider spread together to avoid confusing averages with individuals. Surgical planning requires information from that person’s own knee.

05

It's not a comparison of the entire population of the country.

Participants attended hospitals with symptoms. They were not a random sample of either country’s healthy general population, so the findings should not be generalized to national knee shapes or arthritis incidence.

BMI differences remained after matching for age and sex. Lifestyle and environmental factors may also contribute. This comparison cannot separate genetic background from body build or other explanations for the observed differences.

AI repeatedly measured the same variables across a large set of radiographs. The country comparison does not show that AI can recommend a particular treatment or determine a patient’s future course.

Look at the study numbers again.

16,472Matching before evaluation knee
1:2This is a match of the trend points.
2 countriesComparison between South Korea and the UAE
RESEARCH FINDINGProportion (%)

The percentage of CPAK type 2 in women

UAE women
30.6%
South Korean woman
35.3%
02550
Distribution of CPAK type 2 among women. The predominant type among men differs between the populations.

Common Questions

Can you think of Koreans as a specific type of CPAK?

A type common in a population is not necessarily an individual’s type. Personal alignment must be assessed from that person’s own images.

If the shape of knee is different from that in other countries, how does it feel to be a surgery?

It's a study that showed the distribution of alignment, and it wasn't a direct comparison between the nation-by-nation rankings of surgery laws or the best surgery goals for specific types.

Terms in This Article
CPAK
A classification of knee shape using leg alignment and joint-line obliquity.
The match.
It's a way to match the age and gender of the comparison group.
Methods and Numbers in Detail

Population differences in knee alignment: South Korea and the UAE

Participants and Methods

Before matching: 1,098 participants from the UAE and 7,138 from Korea

AI analyzed radiographs of 2,196 UAE knees and 14,276 Korean knees. Alignment measures and CPAK distributions were compared after 1:2 propensity-score matching for age and sex.

Results Reported in the Paper

  1. Among men, CPAK type 1 was most common in the UAE (42.4%), whereas type 2 was most common in Korea (30.6%).
  2. CPAK type 2 was most common among women in both populations: 30.6% in the UAE and 35.3% in Korea.
  3. In the UAE group, MPTA tended to decrease with increasing age.

Scope of Interpretation

This was a retrospective comparison of symptomatic patients attending hospitals. BMI differences remained after matching, and the groups do not represent the entire populations of their countries.

Keywords

Abstract · Original text

Jisoon Park, Oussama Chaar, Jayakrishnan Narayanakurup, Alamedin Sobhe Abdelsamea Abdelhamead, Du Hyun Ro, Sung Eun Kim. Do knee alignment patterns differ between Middle Eastern and East Asian populations? A propensity-matched analysis using artificial intelligence. Knee surgery & related research. 2025;37(1):11. doi:10.1186/s43019-025-00261-w.

INTRODUCTION

Population-based differences in knee alignment patterns may impact osteoarthritis (OA) progression. This study compares lower extremity alignment in knee OA between Middle Eastern (UAE) and East Asian (South Korean) populations using artificial intelligence (AI)-assisted analysis.

METHODS

A retrospective review included patients with knee symptoms from South Korea (2009-2019) and the United Arab Emirates (UAE) (2015-2024). Exclusion criteria comprised prior knee surgeries, significant bony attrition, and low-quality radiographs. Propensity score matching controlled for age and sex differences between populations. Alignment parameters (hip-knee-ankle angle (HKA), medial proximal tibial angle (MPTA), lateral distal femoral angle (LDFA), and joint line convergence angle (JLCA)) and OA severity (Kellgren-Lawrence (KL) grade) were measured using artificial intelligence (AI) software, along with the analysis of coronal plane alignment of the knee (CPAK) classification. Subanalyses by sex and age group (under 40, 40-60, and over 60 years) were also conducted.

RESULTS

A total of 1098 UAE and 7138 South Korean patients (2196 and 14,276 knees, respectively) were evaluated in this study. Post-matching (1:2), body mass index was significantly higher in UAE patients (p < 0.001). CPAK type 1 was predominant in UAE male patients (42.4%), whereas type 2 was more common in South Korean male patients (30.6%). Female patients in both populations predominantly exhibited CPAK type 2 (UAE 30.6%; South Korea 35.3%). UAE patients showed a lower MPTA with increasing age, indicating a trend toward more varus alignment in older individuals.

CONCLUSIONS

A propensity score-matched analysis revealed significant alignment differences between Middle Eastern and East Asian populations, underscoring the importance of population-specific considerations in OA management.

© The Author(s) 2025